PXD068897

PXD068897 is an original dataset announced via ProteomeXchange.

Title	Enamel proteins from six Homo erectus specimens across China
Description	Homo erectus remains have been found in Africa, Eurasia and Southeast Asia, dating back to 2 million years (Ma), but due to their age and preservation, obtaining informative molecular data from them his been difficult. We successfully extracted ancient enamel proteins from six Middle Pleistocene H. erectus specimens, approximately 0.4 Ma, from the Zhoukoudian, Hexian, and Sunjiadong sites. Five of these specimens are males, and one is female. All specimens from all three sites share two amino acid variants. Of these, AMBN-253G is unknown and has not been seen in other human lineages, including H. erectus from Dmanisi (Georgia), Homo antecessor from Atapuerca (Spain), Denisovans, Neanderthals, and modern humans. The other variant, AMBN-273V, has been previously identified in Denisovans, where it may have been introduced through populations related to these Middle Pleistocene H. erectus. The previously unknown super-archaic segments in Denisovans and later partially passed to modern humans thus likely originated from H. erectus. Late Middle Pleistocene H. erectus may have coexisted with Denisovans in parts of East Asia, where these interactions are presumed to have occurred.
HostingRepository	PRIDE
AnnounceDate	2026-03-22
AnnouncementXML	Submission_2026-03-22_02:37:04.541.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD068897
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Xiao Wang
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	monohydroxylated residue; chlorinated residue; deamidated residue
Instrument	Orbitrap Fusion Lumos; Orbitrap Exploris 480

Revision	Datetime	Status	ChangeLog Entry
0	2025-09-27 19:58:15	ID requested
⏵ 1	2026-03-22 02:37:05	announced

10.6019/PXD068897;

submitter keyword: None

Qiaomei Fu
contact affiliation	Key Laboratory of Vertebrate Evolution and Human Origins, Institute of Vertebrate Paleontology and Paleoanthropology, Chinese Academy of Sciences; College of Earth and Planetary Sciences, University of Chinese Academy of Sciences; Key Research Base on Paleolithic Human Evolution and Paleogenetics (IVPP), SACH
contact email	fuqiaomei@ivpp.ac.cn
lab head
Xiao Wang
contact affiliation	CAS
contact email	wangxiao@ivpp.ac.cn
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD068897
     1. Label: PRIDE project
     2. Name: Enamel proteins from six Homo erectus specimens across China