⮝ Full datasets listing
PXD068888
PXD068888 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Biogenesis of the respiratory chain is controlled by de novo synthesis of cardiolipin in neonatal mouse hearts |
| Description | Postnatal maturation of mammalian heart requires a vast increase in respiratory enzymes. Because the mitochondria-specific lipid cardiolipin (CL) strongly interacts with the respiratory chain, we determined how the two steps of CL biogenesis, de novo synthesis and acyl chain remodeling, affect the maturation of cardiac mitochondria in mice. Cardiomyocyte-restricted deletion of CL synthase in late gestation did not affect CL at birth but blocked the steady increase in the tissue concentration of CL, which we observed during normal postnatal maturation. Deletion of CL synthase also prevented the postnatal rise in the density of cristae and in the intra-mitochondrial concentration of respiratory proteins. This inhibited cardiac development, precipitated heart failure, and caused death by the age of 2 weeks. In contrast, ablation of CL remodeling by cardiomyocyte-restricted deletion of Tafazzin, did not disrupt mitochondrial maturation or cardiac development although it had a similar effect on the CL concentration. Our data show that CL synthesis, but not CL remodeling, controls the expression of the respiratory chain by a mechanism independent of the CL concentration. |
| HostingRepository | MassIVE |
| AnnounceDate | 2026-06-12 |
| AnnouncementXML | Submission_2026-06-12_08:36:36.194.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Non peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Supported dataset by repository |
| PrimarySubmitter | Hediye Erdjument-Bromage |
| SpeciesList | scientific name: Mus musculus; common name: house mouse; NCBI TaxID: 10090; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Q Exactive HF; Q Exactive HF-X |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2025-09-26 21:33:08 | ID requested | |
| ⏵ 1 | 2026-06-12 08:36:36 | announced |
Publication List
| no publication |
Keyword List
| submitter keyword: Cardiolipin, Cardiolipin synthase (Crls1), Tafazzin, Respiratory complexes, Complexome profiling, Mitochondrial maturation, DatasetType:Proteomics |
Contact List
| Dr. Thomas A. Neubert | |
|---|---|
| contact affiliation | New York University School of Medicine |
| contact email | Thomas.Neubert@med.nyu.edu |
| lab head | |
| Dr. Michael Schlame | |
| contact affiliation | New York University School of Medicine |
| contact email | michael.schlame@med.nyu.edu |
| lab head | |
| Hediye Erdjument-Bromage | |
| contact affiliation | New York University School of Medicine |
| contact email | Hediye.Bromage@med.nyu.edu |
| dataset submitter | |
Full Dataset Link List
| MassIVE dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive-ftp.ucsd.edu/v11/MSV000099296/ |
