⮝ Full datasets listing
PXD068880
PXD068880 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Integrated PhosphoProteomic and Kinase Expression Networks Reveal Partial EMT and Adaptive Growth Programs in Pediatric Peutz-Jeghers Polyps |
| Description | Peutz Jeghers syndrome PJS is a rare inherited cancer predisposing disorder. The molecular mechanisms driving polyp initiation and growth are poorly understood thus limiting biomarker identification and pharmacologic strategies to reduce disease burden. We performed mass spectrometry based proteomic and phosphoproteomic profiling of intestinal polyp and adjacent non polyp mucosa from pediatric PJS patients undergoing therapeutic endoscopy polypectomy. Data were integrated through a bioinformatic pipeline and network analyses to identify differential kinase activity, phosphopeptide enrichment, and signaling nodes relevant to polyp growth. |
| HostingRepository | MassIVE |
| AnnounceDate | 2026-03-25 |
| AnnouncementXML | Submission_2026-03-25_07:14:04.942.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Non peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Supported dataset by repository |
| PrimarySubmitter | Michaella Rekowski |
| SpeciesList | scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606; |
| ModificationList | Oxidation; Phospho; Carbamidomethyl |
| Instrument | Orbitrap Ascend |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2025-09-26 14:00:44 | ID requested | |
| ⏵ 1 | 2026-03-25 07:14:05 | announced |
Publication List
| no publication |
Keyword List
| submitter keyword: Peutz Jeghers Syndrome, DatasetType:Proteomics |
Contact List
| Thomas Attard, MD | |
|---|---|
| contact affiliation | Childrens Mercy Hospital |
| contact email | tmattard@cmh.edu |
| lab head | |
| Michaella Rekowski | |
| contact affiliation | University of Kansas Medical Center |
| contact email | mrekowski@kumc.edu |
| dataset submitter | |
Full Dataset Link List
| MassIVE dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive-ftp.ucsd.edu/v11/MSV000099292/ |
