PXD068879 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Secretome translation shaped by Lysosomes and Lunapark-marked ER Junctions |
| Description | Proteomic analysis of membrane fractions from U-2 OS control and Lunapark knockout cells to determine protein abundance per mRNA. Membrane proteins were extracted, digested, and analyzed by DIA LC–MS/MS on a Thermo Orbitrap Ascend Tribrid mass spectrometer with Vanquish Neo LC system |
| HostingRepository | PRIDE |
| AnnounceDate | 2025-12-29 |
| AnnouncementXML | Submission_2025-12-28_16:18:18.354.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Heejun Choi |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | phosphorylated residue; monohydroxylated residue; iodoacetamide derivatized residue |
| Instrument | Orbitrap Ascend |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-09-26 13:42:38 | ID requested | |
| ⏵ 1 | 2025-12-28 16:18:19 | announced | |
Publication List
| 10.1038/s41586-025-09718-0; |
| Choi H, Liao YC, Yoon YJ, Grimm J, Wang N, Lavis LD, Singer RH, Lippincott-Schwartz J, Secretome translation shaped by lysosomes and lunapark-marked ER junctions. Nature, 649(8095):227-236(2026) [pubmed] |
Keyword List
| submitter keyword: lysosome,Lunapark, membrane proteome, ER junctions, secretome mRNA |
Contact List
| Jennifer, Lippincott-Schwartz |
|---|
| contact affiliation | Janelia Research Campus/HHMI |
| contact email | lippincottschwartzj@janelia.hhmi.org |
| lab head | |
| Heejun Choi |
|---|
| contact affiliation | Janelia Research Campus/HHMI |
| contact email | choih@janelia.hhmi.org |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/12/PXD068879 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD068879
- Label: PRIDE project
- Name: Secretome translation shaped by Lysosomes and Lunapark-marked ER Junctions
