PXD068852

PXD068852 is an original dataset announced via ProteomeXchange.

Title	Role of Prx Protein in Starvation Tolerance of Haemaphysalis longicornis
Description	Haemaphysalis longicornis is a blood-sucking ectoparasitic arthropod capable of transmitting various pathogens, posing a serious threat to livestock production and human health. During its prolonged non-parasitic phase, starvation represents one of the major survival challenges it faces. To cope with such nutrient stress, ticks have evolved highly specialized starvation-resistant mechanisms. Previous studies have shown that the expression of peroxiredoxin (Prx) is significantly upregulated in the Malpighian tubules of H. longicornis under starvation. This study further employed techniques such as RNA interference, proteomics, and transmission electron microscopy to systematically investigate the role of Prx in sustaining the survival ability of H. longicornis during prolonged starvation. The experimental results demonstrated that silencing Prx significantly accelerated the mortality of ticks under starvation and induced changes in the expression levels of multiple proteins, indicating that Prx plays a critical role in the starvation stress response. These findings suggest that Prx may serve as a novel molecular target for tick control, with potential application value.
HostingRepository	iProX
AnnounceDate	2025-09-26
AnnouncementXML	Submission_2025-09-25_20:39:16.777.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jiaxuan Han
SpeciesList	scientific name: Haemaphysalis longicornis; NCBI TaxID: 44386;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Exploris 480

Revision	Datetime	Status	ChangeLog Entry
0	2025-09-25 20:38:56	ID requested
⏵ 1	2025-09-25 20:39:17	announced

Dataset with its publication pending

submitter keyword: adaptation, tick, hunger stress, RNA interference, proteomics

Hui Wang
contact affiliation	Hebei Normal University
contact email	whui1981@163.com
lab head
Jiaxuan Han
contact affiliation	Hebei Normal University
contact email	358138711@qq.com
dataset submitter

iProX dataset URI