PXD068736

PXD068736 is an original dataset announced via ProteomeXchange.

Title	Multi-omics of barley Fusarium Head Blight converge on pathogen-triggered biosynthesis of aromatic amino acid derived chemical defense compounds
Description	Fusarium Head Blight (FHB) is a devastating fungal disease of small grain cereals like wheat and barley, causing substantial yield and quality losses each year worldwide. FHB is caused by Fusarium species that produce mycotoxins such as deoxynivalenol (DON) that impairs protein biosynthesis. Although defence responses in barley to Fusarium infection have been described at the transcriptional level, it remains unclear to what extent these responses are translated into functional changes at the protein and metabolite levels. In this study, we employed comprehensive transcriptomics, proteomics, and metabolomics to dissect the defence responses of barley heads during infection with Fusarium culmorum. Our analyses revealed a set of significantly regulated gene-protein pairs linked to biosynthetic pathways that consistently correspond to upregulated defence-related metabolites. These include tryptophan-derived stress metabolites such as tryptamine and serotonin, as well as barley-specific hydroxycinnamylamides, hordatines, and their biosynthetic precursors.
HostingRepository	PRIDE
AnnounceDate	2026-05-18
AnnouncementXML	Submission_2026-05-18_05:54:38.711.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Sophia Hein
SpeciesList	scientific name: Hordeum vulgare (Barley); NCBI TaxID: NEWT:4513;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Eclipse

Revision	Datetime	Status	ChangeLog Entry
0	2025-09-23 05:23:55	ID requested
⏵ 1	2026-05-18 05:54:39	announced

Dataset with its publication pending

submitter keyword: Barley, Fusarium Head Blight

Ralph Hückelhoven
contact affiliation	Chair of Phytopathology, TUM School of Life Sciences Technische Universitaet Muenchen, Freising-Weihenstephan, Germany
contact email	hueckelhoven@tum.de
lab head
Sophia Hein
contact affiliation	Chair of Phytopathology Technische Universitaet Muenchen
contact email	sophia.hein@tum.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD068736

PRIDE project URI

• PRIDE
  1. PXD068736
     1. Label: PRIDE project
     2. Name: Multi-omics of barley Fusarium Head Blight converge on pathogen-triggered biosynthesis of aromatic amino acid derived chemical defense compounds