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PXD068718

PXD068718 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Adipocyte-Specific TMEM41B Deficiency Enhances Bone Formation and Attenuates Osteoporosis via the YY1-Calreticulin Axis
Description	Osteoporosis (OP) is a prevalent skeletal disorder characterized by excessive bone marrow adiposity and impaired osteogenesis. Here, we identify TMEM41B, an endoplasmic reticulum-resident protein, as a critical regulator of bone homeostasis through its actions in bone marrow adipocytes (BMAs). Adipocyte-specific deletion of TMEM41B in mice (TMEM41B AKO) significantly increased bone mass, improved trabecular and cortical bone parameters, and enhanced mechanical strength, particularly in long bones.
HostingRepository	iProX
AnnounceDate	2025-09-23
AnnouncementXML	Submission_2025-09-22_20:14:41.150.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Hui Wang
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	timsTOF Pro

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2025-09-22 20:14:08	ID requested
⏵ 1	2025-09-22 20:14:41	announced

Publication List

Dataset with its publication pending

Keyword List

submitter keyword: Bone

Contact List

Tiemin Liu
contact affiliation	Fudan University
contact email	tiemin_liu@fudan.edu.cn
lab head
Hui Wang
contact affiliation	Fudan University
contact email	tangguodidi222@163.com
dataset submitter

Full Dataset Link List

iProX dataset URI