PXD068629

PXD068629 is an original dataset announced via ProteomeXchange.

Title	A PSAT1 buff of YBX1 transcriptionally sustains HLA-E-mediated evasion of NK immunity
Description	Despite great success in certain cancers, immunotherapy made little progress in treating immune “cold” tumors, like prostate cancer, largely attributed to an immunesuppressive tumor microenvironment with elusive mechanisms. Here, we report in prostate cancer cells a positive feed-back loop driven by PSAT1 that could be targeted to render effective cytotherapy by NK cells. In the loop, PSAT1 increases YBX1 phosphorylation by MARK2, promoting its nuclear translocation to upregulate PSAT1 transcription. Meanwhile, YBX1 also promotes HLA-E transcription, a ligand for inhibitory KIRs inactivating NK cells. As a result, the PSAT1 loop serves as a buff to sustain YBX1 and HLA-E expression, suppressing NK killing of prostate cancer cells.
HostingRepository	iProX
AnnounceDate	2025-09-19
AnnouncementXML	Submission_2025-09-23_19:53:57.854.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Chaobing Ma
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2025-09-21 23:50:01	ID requested
1	2025-09-21 23:50:18	announced
⏵ 2	2025-09-23 19:53:58	announced	2025-09-24: update info

Dataset with its publication pending

submitter keyword: Immunotherapy, prostate cancer, cytotherapy, NK immunity, PSAT1

Qiang Sun
contact affiliation	Beijing Institute of Biotechnology; Research Unit of Cell Death Mechanism, 2021RU008, Chinese Academy of Medical Science, Beijing
contact email	SUNQ@BMI.AC.CN
lab head
Chaobing Ma
contact affiliation	Department of Experimental Medicine, TOR, University of Rome "Tor Vergata"
contact email	643559943@qq.com
dataset submitter

iProX dataset URI