PXD068613

PXD068613 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Proteomics analysis of Vitamin C in people with type 2 diabetes
Description	A double-blind, placebo-controlled, cross-over trial was undertaken in people with T2D, who were administered 1000mg/day ascorbic acid or placebo for 4-months. Plasma proteins in 26 participants (22 male, 4 female, age 62.6±6.5 years, HbA1c 7.6±0.7%) were quantified by liquid chromatography/mass spectrometry with data independent acquisition. Differential protein expression was assessed for: VC post-supplementation vs. placebo post-supplementation; and VC post-supplementation vs. control [pooling of all non-active conditions]. Pathway enrichments were explored, and correlations between differentially expressed proteins and significantly improved clinical outcomes were assessed.
HostingRepository	PRIDE
AnnounceDate	2026-07-02
AnnouncementXML	Submission_2026-07-02_01:52:12.058.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Shaun Mason
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Exploris 240

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2025-09-20 23:43:52	ID requested
⏵ 1	2026-07-02 01:52:13	announced

Publication List

10.1038/s41387-026-00447-5;
Van Grunsven T, Wadley GD, Mason SA, Plasma proteomics analysis of vitamin C supplementation in people with type 2 diabetes. Nutr Diabetes, ():(2026) [pubmed]

10.1038/s41387-026-00447-5;

Van Grunsven T, Wadley GD, Mason SA, Plasma proteomics analysis of vitamin C supplementation in people with type 2 diabetes. Nutr Diabetes, ():(2026) [pubmed]

Keyword List

submitter keyword: proteomics,type 2 diabetes, ascorbic acid, vitamin C, clinical trial

submitter keyword: proteomics,type 2 diabetes, ascorbic acid, vitamin C, clinical trial

Contact List

Shaun Mason
contact affiliation	Deakin University
contact email	s.mason@deakin.edu.au
lab head
Shaun Mason
contact affiliation	Deakin University
contact email	s.mason@deakin.edu.au
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/07/PXD068613
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/07/PXD068613

PRIDE project URI

Repository Record List

[ + ]