PXD068607

PXD068607 is an original dataset announced via ProteomeXchange.

Title	CD177 deficiency defines a stable subtype of human neutrophil granulocytes
Description	CD177 is a surface protein on human neutrophil granulocytes whose function is related, but not limited to, tissue infiltration. While a fraction of the population is completely CD177-deficient (CD177d), most individuals express CD177. Expression levels on cells are not uniform and in every individual a proportion of neutrophils is CD177d. Evidence is increasing that CD177 expressing (CD177e) neutrophils differ functionally from CD177d-cells and influence disease outcomes. Whether CD177e is a status ultimately reached by any neutrophil, also initially CD177d-cells, is unclear. This study characterized these two subtypes using LC-MS based label free quantitative proteomics. The proteomics data suggests distinct proteome composition of these two subtypes despite of having morphological similarity. Interestingly, CD177d-cells were found to present an N2-polarized phenotype based on protein expression, which are preferentially enriched in human head-and-neck cancers.
HostingRepository	PRIDE
AnnounceDate	2026-09-07
AnnouncementXML	Submission_2026-09-06_18:04:33.434.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Susmita Ghosh
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	iodoacetamide derivatized residue
Instrument	timsTOF HT

Revision	Datetime	Status	ChangeLog Entry
0	2025-09-20 10:55:03	ID requested
⏵ 1	2026-09-06 18:04:34	announced

Jung M, Beer A, Ghosh S, Pylaeva E, Alshaar B, Tertel T, Leimk, ü, hler NB, Schroeder T, Gronewold J, Hagemann N, Mohamud Yusuf A, Frank B, Zhang Y, Nagel D, Schloe, ß, er K, Karsch L, Hedtfeld E, Lohmann S, Blank K, Kraus A, Krumbein M, Kabankova N, Wang H, Bader A, Richter M, Zhang F, Chevre R, Giebel B, Lang S, Gr, ü, neboom A, Maier-Begandt D, Hasenberg A, Soehnlein O, Reinhardt HC, Heiles S, Chen J, Jablonska J, Sickmann A, Hermann DM, Gunzer M, CD177 Deficiency Defines a Stable Subtype of Human Neutrophil Granulocytes with Tumor Promoting Activity. Adv Sci (Weinh), ():e76236(2026) [pubmed]

10.1002/advs.76236;

submitter keyword: Human neutrophils, proteomics, circulation, inflammation, LFQ, CD177

Albert Sickmann
contact affiliation	Leibniz-Institut für Analytische Wissenschaften – ISAS – e.V.
contact email	albert.sickmann@isas.de
lab head
Susmita Ghosh
contact affiliation	Leibniz-Institut für Analytische Wissenschaften – ISAS – e.V.
contact email	susmita.ghosh@isas.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/09/PXD068607

PRIDE project URI

• PRIDE
  1. PXD068607
     1. Label: PRIDE project
     2. Name: CD177 deficiency defines a stable subtype of human neutrophil granulocytes