PXD068594

PXD068594 is an original dataset announced via ProteomeXchange.

Title	Profiling of activated RBR E3 ligases using E2V derived activity-based probes
Description	Structure-based E2 enzyme variants (E2Vs) were used to create biotinylated activity-based probes use as handles for affinity purification-mass spectrometry to identify interacting E3s.
HostingRepository	PRIDE
AnnounceDate	2026-01-05
AnnouncementXML	Submission_2026-01-05_02:14:52.987.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Gisele Andree
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	timsTOF Pro 2

Revision	Datetime	Status	ChangeLog Entry
0	2025-09-19 13:37:25	ID requested
⏵ 1	2026-01-05 02:14:54	announced

10.1073/pnas.2524899122;

submitter keyword: E2 enzyme,E3 ligase, activity-based probe

Brenda Schulman
contact affiliation	Department of Molecular Machines and Signaling, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany
contact email	schulman@biochem.mpg.de
lab head
Gisele Andree
contact affiliation	MPIB
contact email	andree@biochem.mpg.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/01/PXD068594

PRIDE project URI

• PRIDE
  1. PXD068594
     1. Label: PRIDE project
     2. Name: Profiling of activated RBR E3 ligases using E2V derived activity-based probes