PXD068480

PXD068480 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Effects of clozapine and risperidone on the proteome of human neurons derived from Lund Human Mesencephalic (LUHMES) cells
Description	This study investigates the molecular mechanisms of action of clozapine and risperidone in human neurons derived from Lund Human Mesencephalic (LUHMES) cells. A DDA and DIA proteomic approach was employed to capture comprehensive changes in protein expression induced by chronic (72 hours) antipsychotic drug treatment. Additionally to the whole-cell lysate, the nuclear sub-proteome of LUHMES neurons was analysed using the DIA approach.
HostingRepository	MassIVE
AnnounceDate	2025-09-18
AnnouncementXML	Submission_2025-09-18_06:50:23.720.xml
DigitalObjectIdentifier
ReviewLevel	Non peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Patrycja Sarga
SpeciesList	scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606;
ModificationList	Oxidation; Carbamidomethyl; Acetyl
Instrument	Orbitrap Astral; Orbitrap Exploris 480

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2025-09-18 04:12:43	ID requested
⏵ 1	2025-09-18 06:50:24	announced

Publication List

no publication

no publication

Keyword List

submitter keyword: human neurons, risperidone, clozapine, LUHMES, LS-MS/MS, DatasetType:Proteomics

submitter keyword: human neurons, risperidone, clozapine, LUHMES, LS-MS/MS, DatasetType:Proteomics

Contact List

Sylwia Kedracka-Krok
contact affiliation	Department of Physical Biochemistry, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland
contact email	sylwia.kedracka-krok@uj.edu.pl
lab head
Patrycja Sarga
contact affiliation	Jagiellonian University
contact email	patrycja.sarga@uj.edu.pl
dataset submitter

Full Dataset Link List

MassIVE dataset URI
Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive-ftp.ucsd.edu/v10/MSV000099217/

MassIVE dataset URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive-ftp.ucsd.edu/v10/MSV000099217/