PXD068472

PXD068472 is an original dataset announced via ProteomeXchange.

Title	Temporal Multi-Omics Identifies ZG16 as a Prognostic Immunoregulatory Driver of Colitis-associated Colon Cancer Development and Checkpoint Blockade Response
Description	This dataset contains quantitative proteomic profiles across five disease stages (W0, W2, W5, W8, W11) of colitis-associated colorectal cancer (CAC) using a mouse AOM/DSS model. Proteins were extracted from tumor tissues and processed for LC-MS/MS after labeling with iTRAQ 8-plex reagents. The goal was to identify temporal dynamics of protein expression underlying chronic inflammation-induced tumorigenesis.
HostingRepository	iProX
AnnounceDate	2025-09-16
AnnouncementXML	Submission_2025-09-17_23:43:03.337.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Lu Chen
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	TripleTOF 5600

Revision	Datetime	Status	ChangeLog Entry
0	2025-09-17 23:42:15	ID requested
⏵ 1	2025-09-17 23:43:03	announced

Dataset with its publication pending

submitter keyword: Colitis-associated colorectal cancer, Immune checkpoint therapy, Tumor microenvironment, ZG16, Time-series multi-omics, PD-L1 regulation, CD8+ T cells

Weiguo Hu
contact affiliation	Shanghai Cancer Center, Fudan University
contact email	weiguohu@fudan.edu.cn
lab head
Lu Chen
contact affiliation	Shanghai Cancer Center, Fudan University
contact email	20111230014@fudan.edu.cn
dataset submitter

iProX dataset URI