PXD068377 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Investigate the proteomic profiles of calf faecal extracellular vesicles: investigating gut health and infectious disease associated changes in calves |
| Description | Faeces are considered easily accessible biological specimens that can be used to monitor gastrointestinal disorders. Extracellular vesicles (EVs) can be enriched from calf faeces, and these faecal extracellular vesicles (fEVs) consist of a diverse range of biological molecules, such as proteins, DNA, and RNA. The double membrane of EVs and the charged corona preserve their cargo, including proteins, from proteases, nucleases, and harsh environmental conditions. This enables the recovery of intact proteins secreted by the host and GI tract organisms, preserving their natural structure and function. While fEVs are suggested to mediate inter-species communication in the GI tract, the role of their protein cargo in GI infections remains unclear. Therefore, this study aimed to investigate the possibility of using fEVs as a non-invasive tool to investigate gut health and infections in claves. We considered Cryptosporidiosis as a model gut disease in calves to study the alteration in the proteomic profile of fEVs under gut infections. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-01-23 |
| AnnouncementXML | Submission_2026-01-23_01:24:50.957.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Chanaka Premathilaka |
| SpeciesList | scientific name: Bos taurus (Bovine); NCBI TaxID: NEWT:9913; |
| ModificationList | acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue |
| Instrument | Q Exactive |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-09-15 05:26:56 | ID requested | |
| ⏵ 1 | 2026-01-23 01:24:51 | announced | |
Publication List
| 10.1186/s40104-025-01332-4; |
| Premathilaka C, Godakumara K, Peffers MJ, Clarke EJ, Dorbek-Sundstr, รถ, m E, Orro T, Kodithuwakku S, Fazeli A, Cryptosporidium spp. infection drives distinct alterations in the faecal extracellular vesicles metaproteome of calves. J Anim Sci Biotechnol, 17(1):8(2026) [pubmed] |
Keyword List
| submitter keyword: Gut infections, Proteomics,Faecal, Extracellular vesicles |
Contact List
| Alireza Fazeli |
|---|
| contact affiliation | Institute of Veterinary Medicine and Animal Sciences, Estonian University of Life Sciences, Tartu, Estonia |
| contact email | alireza.fazeli@emu.ee |
| lab head | |
| Chanaka Premathilaka |
|---|
| contact affiliation | PhD student |
| contact email | chanakanpdn@gmail.com |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/01/PXD068377 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD068377
- Label: PRIDE project
- Name: Investigate the proteomic profiles of calf faecal extracellular vesicles: investigating gut health and infectious disease associated changes in calves
