PXD068356
PXD068356 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Dual-Omics Mapping of Tinnitus Phenotype Transition in Noise-Exposed Auditory Cortex-2 |
| Description | This study resolves a critical paradox: why noise-induced hearing loss (NIHL) does not universally progress to tinnitus. Through integrated proteomics and phosphoproteomics of auditory cortex tissue, we establish that tinnitus pathogenesis is driven by phosphorylation-mediated network dysregulation, fundamentally distinct from NIHL’s transcriptional-level changes. |
| HostingRepository | iProX |
| AnnounceDate | 2025-09-14 |
| AnnouncementXML | Submission_2025-09-14_01:58:33.635.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Zhixin Zhang |
| SpeciesList | scientific name: Mus musculus; NCBI TaxID: 10090; |
| ModificationList | phosphorylated residue |
| Instrument | timsTOF Pro |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2025-09-14 01:57:53 | ID requested | |
| ⏵ 1 | 2025-09-14 01:58:34 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Noise-induced hearing loss, Tinnitus, Membrane receptors, Excitability, Proteomics, Phosphorylation |
Contact List
| Fangyuan Wang | |
|---|---|
| contact affiliation | Chinese PLA Medical School |
| contact email | 1093749813@qq.com |
| lab head | |
| Zhixin Zhang | |
| contact affiliation | Chinese PLA Medical School |
| contact email | zhangzhixin0246@126.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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