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PXD068354
PXD068354 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Comparative proteomic analysis of outer membrane vesicles from Vibrio parahaemolyticus and highly lethal Vibrio parahaemolyticus |
| Description | Acute hepatopancreatic necrosis disease (AHPND) is a major shrimp disease caused by specific strains of Vibrio parahaemolyticus (VpAHPND). More recently, a newly emerged outbreak known as translucent post-larvae disease (TPD), caused by highly lethal Vibrio parahaemolyticus (HLV), has severely impacted the shrimp aquaculture industry due to its extremely high mortality in Litopenaeus vannamei. Outer membrane vesicles (OMVs), nanoscale extracellular structures secreted by vibrios, play crucial roles in virulence factor delivery and host-pathogen interactions. In this study, we conducted a systematic proteomic comparison of OMVs derived from VpAHPND and HLV. The results showed that both types of OMVs exhibited typical features of Gram-negative bacteria and shared a large number of conserved proteins associated with outer membrane maintenance, nutrient transport, and basic metabolic processes, suggesting common roles in fundamental physiology and host interactions. However, notable differences were also observed. Specifically, compared with VpAHPND-OMVs, HLV-OMVs were enriched with proteins related to toxins, secretion systems, immune modulation, and metabolic adaptation. These findings suggest that HLV-OMVs may possess enhanced capabilities to promote host infection, evade immune defenses, and adapt to environmental stress. Overall, this study not only reveals the shared characteristics of VpAHPND-OMVs and HLV-OMVs but also highlights the unique protein composition of HLV, providing an important proteomic resource for elucidating the pathogenic mechanisms of V. parahaemolyticus from the perspective of OMVs. |
| HostingRepository | iProX |
| AnnounceDate | 2025-09-14 |
| AnnouncementXML | Submission_2025-12-30_23:56:34.650.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Lihan Wang |
| SpeciesList | scientific name: Vibrio parahaemolyticus VP2007-007; NCBI TaxID: 1238192; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | timsTOF Pro |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2025-09-14 01:55:43 | ID requested | |
| ⏵ 1 | 2025-12-30 23:56:35 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Vibrio parahaemolyticus, highly lethal Vibrio parahaemolyticus, Outer Membrane vesicles protein |
Contact List
| Mengqiang Wang | |
|---|---|
| contact affiliation | Ocean University of China |
| contact email | wangmengqiang@ouc.edu.cn |
| lab head | |
| Lihan Wang | |
| contact affiliation | Ocean University of China |
| contact email | 2648181506@qq.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
