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PXD068345

PXD068345 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Proteomic analysis of differential proteins between PCOS and tubular infertility luteinized granulosa cells (GCs)
Description	Polycystic ovary syndrome (PCOS) is a prevalent heterogeneous endocrine disorder affecting 10–20% of reproductive-aged women worldwide. To investigate its link to metabolic dysfunction, we compared granulosa cells (GCs) from eight PCOS patients and four controls (with tubular infertility) undergoing in vitro fertilization (IVF). Using high-resolution liquid chromatography-tandem mass spectrometry (LC-MS/MS), we identified 430 differentially expressed proteins. Gene ontology (GO) analysis revealed that metabolic processes were significantly enriched, constituting 7 of the top 13 pathways, thereby underscoring the central role of metabolic dysfunction in PCOS pathogenesis.
HostingRepository	iProX
AnnounceDate	2025-09-13
AnnouncementXML	Submission_2025-09-13_23:43:54.551.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Chuanjin Yu
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	timsTOF Pro

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2025-09-13 23:43:39	ID requested
⏵ 1	2025-09-13 23:43:54	announced

Publication List

Dataset with its publication pending

Keyword List

submitter keyword: Proteomic, granulosa cells, PCOS

Contact List

Hefeng Huang
contact affiliation	Institute of Reproduction and Development, Jiai genetic & IVF institute, Obstetrics and Gynecology Hospital, Fudan University
contact email	huanghefg@hotmail.com
lab head
Chuanjin Yu
contact affiliation	Institute of Reproduction and Development, Fudan University
contact email	yuchuanjin1013@163.com
dataset submitter

Full Dataset Link List

iProX dataset URI