PXD068303 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Melatonin Rescues Triclosan-Disrupted Porcine Oocyte Meiosis via Suppression of p53-Mediated Apoptosis |
| Description | This study investigates the toxic effects of the environmental contaminant triclosan (TCS) on porcine oocyte meiosis and the protective role of melatonin (MT). Using an in vitro maturation model, TCS was found to impair polar body extrusion and cumulus expansion, while inducing oxidative stress, mitochondrial and endoplasmic reticulum dysfunction, and apoptosis. To explore the underlying molecular mechanisms, we performed proteomic profiling using a Bruker timsTOF Pro2 mass spectrometer with a Direct DIA acquisition strategy. Differentially expressed proteins (DEPs) were quantified and analyzed using Spectronaut software, followed by functional annotation and enrichment analysis via GO, KEGG, and Reactome databases. The results revealed that the p53 signaling pathway plays a central role in both TCS-induced toxicity and MT-mediated rescue, providing new insights into reproductive damage caused by environmental pollutants. |
| HostingRepository | PRIDE |
| AnnounceDate | 2025-11-17 |
| AnnouncementXML | Submission_2025-11-16_16:39:15.170.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Ning Zhao |
| SpeciesList | scientific name: Sus scrofa (Pig); NCBI TaxID: NEWT:9823; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | timsTOF Pro 2 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-09-11 21:20:25 | ID requested | |
| ⏵ 1 | 2025-11-16 16:39:16 | announced | |
Publication List
| Duan J, Zhao N, Wang S, Li X, Li B, Cao G, Melatonin Rescues Triclosan-Disrupted Porcine Oocyte Meiosis via Suppression of p53-Mediated Apoptosis. Animals (Basel), 15(21):(2025) [pubmed] |
| 10.3390/ani15213193; |
Keyword List
| submitter keyword: Porcine oocytes |
| Melatonin |
| Triclosan |
| Apoptosis |
| p53 |
Contact List
| Guoqing Cao |
|---|
| contact affiliation | College of Animal Science, Shanxi Agricultural University |
| contact email | anniecao710502@aliyun.com |
| lab head | |
| Ning Zhao |
|---|
| contact affiliation | Shanxi Agricultural University |
| contact email | z18434764303n@163.com |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
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| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD068303
- Label: PRIDE project
- Name: Melatonin Rescues Triclosan-Disrupted Porcine Oocyte Meiosis via Suppression of p53-Mediated Apoptosis
