PXD068289 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Proteomics of PLGA-based nanoparticles protein corona after mild isolation and its impact on macrophage uptake (PLGA100). |
| Description | Recognition of the protein corona, a layer of adsorbed protein around nanosystems, is necessary for a better understanding of bio-nano interaction. This study first compares different experimental methods for PLGA nanoparticles protein corona isolation, then investigated the biological identity and fingerprint profile of adsorbed proteins on variously pegylated PLGA-based nanoparticles using microfiltration as an ideal isolation method coupled with proteomics. The total proteins identified in the corona of nanoparticles with different compositions were classified based on their abundance and gene-ontology. Lastly, measurements of nanoparticles absorption by macrophages showed a strong association with the characteristics of the protein corona. |
| HostingRepository | PRIDE |
| AnnounceDate | 2025-11-04 |
| AnnouncementXML | Submission_2025-11-04_08:13:45.206.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Lucio Spinelli |
| SpeciesList | scientific name: Bos taurus (Bovine); NCBI TaxID: NEWT:9913; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Eclipse |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-09-11 05:26:53 | ID requested | |
| ⏵ 1 | 2025-11-04 08:13:45 | announced | |
Publication List
Keyword List
Contact List
| Maria Chiara |
|---|
| contact affiliation | University of Naples Federico II |
| contact email | mariachiara.monti@unina.it |
| lab head | |
| Lucio Spinelli |
|---|
| contact affiliation | University of Naples Federico II |
| contact email | lucio.spinelli@unina.it |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/11/PXD068289 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD068289
- Label: PRIDE project
- Name: Proteomics of PLGA-based nanoparticles protein corona after mild isolation and its impact on macrophage uptake (PLGA100).
