PXD068273

PXD068273 is an original dataset announced via ProteomeXchange.

Title	The Chiglitazar perturbed Human multi-Omics ProfilE (ChiHOPE) project
Description	The Chiglitazar perturbed Human multi-Omics ProfilE (ChiHOPE) project aimed at benefiting precision medicine of type 2 diabetes with multi-omics profiling. Chiglitazar, also known as Carfloglitazar, is an orally administered, non-thiazolidinedione small-molecule agonist of the α, δ and γ subtypes of the peroxisome proliferator-activated receptors (PPARs) developed by Chipscreen Biosciences. Since October 2021, Chiglitazar has been approved in China for use as an adjunct to diet and exercise to improve glycemic control in adult patients with T2D, and is also in phase 2 clinical development for the treatment of metabolic dysfunction-associated steatohepatitis (MASH). We constructed the ChiHOPE cohort of 835 drug-naïve patients with T2D, who were consented for this companion multi-omics study and represented 65% of the 1,274 patients participating in the two randomized, double-blind, phase 3 trials of the insulin sensitizer chiglitazar. The placebo-controlled CMAP trial (NCT02121717, ClinicalTrials.gov) included 350 patients randomly assigned to receive low dose (32 mg/day, n = 106), high dose (48 mg/day, n = 106) chiglitazar and placebo (n = 138) for treatment. The Sitagliptin-controlled CMAS trial (NCT02173457, ClinicalTrials.gov) included 485 patients randomly assigned to receive low dose (n = 161), high dose (n = 161) chiglitazar and sitagliptin (n = 163) for treatment. Multi-omics datasets were generated from longitudinally collected blood samples of patients at baseline, treated for 12 weeks and 24 weeks during trials. Specifically, genomic and methylomic data were generated from whole blood samples (n = 834) at baseline, whereas miRNAomic, proteomic and metabolomic data were generated from plasma samples at different time points (n = 2,190). Stringent quality control (QC) procedures were implemented to generate high-quality multi-omics datasets. Here are Proteomics data provided.
HostingRepository	iProX
AnnounceDate	2025-09-11
AnnouncementXML	Submission_2025-09-10_19:37:46.034.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Qiaochu Chen
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF-X

Revision	Datetime	Status	ChangeLog Entry
0	2025-09-10 19:34:27	ID requested
⏵ 1	2025-09-10 19:37:46	announced

Dataset with its publication pending

submitter keyword: Chiglitazar, Carfloglitazar, proteomics, type 2 diabetes, CMAP,CMAS

Yuanting Zheng
contact affiliation	Fudan University
contact email	zhengyuanting@fudan.edu.cn
lab head
Qiaochu Chen
contact affiliation	Fudan University
contact email	chenqc21@m.fudan.edu.cn
dataset submitter

iProX dataset URI