PXD068263

PXD068263 is an original dataset announced via ProteomeXchange.

Title	HDX-MS of Importin 7 and C terminal of HIV-1 integrase complex
Description	This project investigates the interaction between Importin 7 (Imp7), a nuclear transport receptor, and HIV-1 Integrase (IN), a viral enzyme essential for integration of viral DNA into the host genome. To characterize the molecular basis of this interaction, we performed hydrogen–deuterium exchange mass spectrometry (HDX-MS). The Imp7–IN complex was expressed, purified, and subjected to HDX under defined conditions, followed by pepsin digestion and LC-MS/MS analysis. TheHDX-MS results reveal the specific regions in Imp7 that interact with the C terminal of HIV-IN, providing mechanistic insights into their interaction. All raw HDX-MS data files, peptide identifications, and metadata are included in this submission.
HostingRepository	PRIDE
AnnounceDate	2026-09-07
AnnouncementXML	Submission_2026-09-06_16:39:35.941.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Juana Bana
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	No PTMs are included in the dataset
Instrument	Synapt MS

Revision	Datetime	Status	ChangeLog Entry
0	2025-09-10 14:47:17	ID requested
⏵ 1	2026-09-06 16:39:36	announced

10.1002/2211-5463.70294;

Bana J, Yariv A, Oppenheim T, Amartely H, Reichmann D, Livnah O, Importin 7 mediates the nuclear import of HIV-1 integrase via a specific interacting interface. FEBS Open Bio, ():(2026) [pubmed]

submitter keyword: karyopherins, HIV,Nulear transport

Oded Livnah
contact affiliation	Department of Biological Chemistry, Alexander Silverman Institute of Life Sciences, The Edmond J. Safra Campus, The Hebrew University of Jerusalem, Jerusalem, 9190401, Israel. (lab head)
contact email	oded.livnah@mail.huji.ac.il
lab head
Juana Bana
contact affiliation	The Hebrew University of Jerusalem
contact email	juana.bana@mail.huji.ac.il
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/09/PXD068263

PRIDE project URI

• PRIDE
  1. PXD068263
     1. Label: PRIDE project
     2. Name: HDX-MS of Importin 7 and C terminal of HIV-1 integrase complex