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PXD068216

PXD068216 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	FAM135B deficiency inhibits cytotoxic T cell activity in triple-negative breast cancer by blocking the IFI16-dependent STING pathway
Description	FAM135B interacts with IFI16, inhibiting its ubiquitination and proteasomal degradation by competitively blocking its binding to the E3 ligase TRIM21, thereby initiating the IFI16-dependent STING signaling, ultimately leading to increased cytotoxic T cell activity.
HostingRepository	iProX
AnnounceDate	2025-09-09
AnnouncementXML	Submission_2025-09-09_01:22:35.287.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Wanmei Lin
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2025-09-09 01:22:15	ID requested
⏵ 1	2025-09-09 01:22:35	announced

Publication List

Dataset with its publication pending

Keyword List

submitter keyword: FAM135B, IFI16, ubiquitination

Contact List

Guangyu Yao
contact affiliation	Breast Center, Department of General Surgery, Nanfang Hospital, Southern Medical University
contact email	yaogy@smu.edu.cn
lab head
Wanmei Lin
contact affiliation	Southern Medical University
contact email	718395484@qq.com
dataset submitter

Full Dataset Link List

iProX dataset URI