PXD068152

PXD068152 is an original dataset announced via ProteomeXchange.

Title	The cancer-suppressive tapeworm Mesocestoides corti: larval transcriptome, proteome, and functional characterization of its McKI-C1 Kunitz-type protease inhibitor
Description	Cancer remains positioned as the leading cause of death worldwide, with nearly 10 million deaths and an estimated 20 million new cases yearly. Here, we present analyses of molecular data from the tumor-suppressing larvae of the tapeworm Mesocestoides corti, the intraperitoneal infection of which has previously demonstrated the ability to abrogate the growth and metastasis of the highly aggressive B16F10 melanoma in mice. In order to explore the potential effector mechanisms and molecules behind its cancer-suppressive capabilities, we analyzed the M. corti larval transcriptome in the C57BL/6J and ICR mouse strains, as well as in vitro, and the proteomic profiles of whole worm homogenate and its excretory-secretory products. We present, thus far, the most extensive list of experimentally verified M. corti protein products. These were searched for molecules potentially responsible for the tapeworm’s immune-related cancer-suppressive abilities. Many proteins with potential immunomodulatory properties were found within its proteome, including those from the cysteine-rich secretory CAP family, such as GLIPR-like proteins. Furthermore, functional tests of McKI-C1, an ortholog of the anti-cancer Kunitz inhibitor EgKI-1 from Echinococcus granulosus, were performed both in vitro and in vivo, to ascertain whether it could express a similar effect. While McKI-C1 did not show itself as an effector molecule in the tapeworm’s cancer-suppressive abilities, the extensive list of potentially functional molecules prompts further exploration.
HostingRepository	PRIDE
AnnounceDate	2026-06-15
AnnouncementXML	Submission_2026-06-14_16:19:51.541.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jana Jasprova
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090; scientific name: Mesocestoides corti; NCBI TaxID: NEWT:53468;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Ascend

Revision	Datetime	Status	ChangeLog Entry
0	2025-09-07 23:36:49	ID requested
⏵ 1	2026-06-14 16:19:52	announced

Vajs V, Mike, š L, Leontovy, č R, Tulpov, á M, Koren, á L, Tolde O, Mach, á, č, ek T, Br, á, bek J, R, ö, sel D, Hor, á, k P, Integrated transcriptomic and proteomic analysis of cancer-suppressive Mesocestoides corti larvae. Parasit Vectors, 19(1):(2026) [pubmed]

10.1186/s13071-026-07391-4;

submitter keyword: tetrathyridium, transcriptome, Mesocestoides,cancer, tumor suppression, Kunitz, tapeworm, proteome, metastasis

Vojtěch Vajs
contact affiliation	Department of Parasitology, Faculty of Science, Charles University, Viničná 7, 12844 Prague 2, Czech Republic
contact email	vojte.vajs@gmail.com
lab head
Jana Jasprova
contact affiliation	Charles University, Faculty of Science
contact email	vanikova@natur.cuni.cz
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD068152

PRIDE project URI

• PRIDE
  1. PXD068152
     1. Label: PRIDE project
     2. Name: The cancer-suppressive tapeworm Mesocestoides corti: larval transcriptome, proteome, and functional characterization of its McKI-C1 Kunitz-type protease inhibitor