PXD068151 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Effect of 3’,4’-dihydroxyflavonol eye drops in a rat model of dispase-induced proliferative vitreoretinopathy |
| Description | Proliferative vitreoretinopathy (PVR) was induced in a rat model using intravitreal dispase to study fibrosis- and inflammation-related proteome changes and to evaluate the therapeutic effect of topical 3’,4’-dihydroxyflavonol (DiOHF) eye drops. Retina and vitreous were collected 28 days post-injury from vehicle-, DiOHF- and methotrexate-treated eyes, alongside contralateral controls. In parallel, ARPE-19 cells were stimulated with TGFβ1 + PDGF-BB to model wound-healing responses in vitro, with or without DiOHF. Label-free DIA LC-MS/MS was performed (Orbitrap Exploris 480 for rat tissues; Orbitrap Eclipse for ARPE-19), and data were analyzed with Spectronaut directDIA against UniProt Rattus norvegicus or Homo sapiens canonical databases. The dataset contains the original instrument raw files and processed Spectronaut results for both the rat retina/vitreous and ARPE-19 experiments. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-01-05 |
| AnnouncementXML | Submission_2026-01-04_17:12:07.176.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | cheng zeng |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Eclipse |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-09-07 23:06:16 | ID requested | |
| ⏵ 1 | 2026-01-04 17:12:08 | announced | |
Publication List
| 10.3390/antiox14121414; |
| Chan EC, Zeng C, Luu CD, Abbott CJ, Chan NT, Datta KK, Williamson N, Allen PJ, Fan Gaskin JC, Effect of 3',4'-Dihydroxyflavonol Eye Drops in a Rat Model of Dispase-Induced Proliferative Vitreoretinopathy. Antioxidants (Basel), 14(12):(2025) [pubmed] |
Keyword List
| submitter keyword: ARPE-19, 3’,4’-dihydroxyflavonol, proliferative vitreoretinopathy |
| proteomics |
| rat mod-el of dispase-induced PVR. |
Contact List
| Cheng Zeng |
|---|
| contact affiliation | Centre For Eye Research Australia(CERA) |
| contact email | chengzeng0909@gmail.com |
| lab head | |
| cheng zeng |
|---|
| contact affiliation | The Centre for Eye Research Australia(CERA) |
| contact email | chengzeng0909@gmail.com |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/01/PXD068151 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD068151
- Label: PRIDE project
- Name: Effect of 3’,4’-dihydroxyflavonol eye drops in a rat model of dispase-induced proliferative vitreoretinopathy
