PXD068105

PXD068105 is an original dataset announced via ProteomeXchange.

Title	Integrated Multi-omics Profiling of Mouse Brain Tissue Using the AllPrep Methods versus Traditional Extraction Methods
Description	In the exploration of complex biological systems, integrated multi-omics analysis has emerged as a pivotal strategy for deciphering molecular interaction networks. However, traditional stepwise extraction methods are prone to technical biases introduced by tissue spatial heterogeneity and repeated processing, limiting the accuracy and comparability of results. Although existing co-extraction techniques enable efficient and sequential isolation of nucleic acids (DNA/RNA) and proteins from the same sample, a significant methodological gap remains in systematically evaluating their performance in integrated multi-omics studies. Addressing this critical issue, this study thoroughly investigated the performance of a co-extraction strategy (AllPrep) in multi-omics research using spatially heterogeneous mouse brain tissues.
HostingRepository	iProX
AnnounceDate	2025-09-05
AnnouncementXML	Submission_2026-03-02_17:59:32.638.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Xianfeng Shao
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	phosphorylated residue
Instrument	Orbitrap Exploris 480

Revision	Datetime	Status	ChangeLog Entry
0	2025-09-04 20:32:29	ID requested
⏵ 1	2026-03-02 17:59:33	announced

Dataset with its publication pending

submitter keyword: AllPrep, Multi-omics, co-extraction

Hong Wang
contact affiliation	State Key Laboratory of Experimental Hematology
contact email	wanghong@ihcams.ac.cn
lab head
Xianfeng Shao
contact affiliation	State Key Laboratory of Experimental Hematology
contact email	shaoxf965596769@163.com
dataset submitter

iProX dataset URI