PXD068087 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Mitochondrial protein lactylation in myocardial infarction |
| Description | Lactylation, a novel post-translational modification (PTM), in which a lactyl group, derived from lactate, is covalently added to lysine residues on the target proteins. Lactylation, first observed in histones in 2019, is increasingly recognized for its influence on gene expression, especially as it relates to shifts in cellular metabolism. ‘Metabolic reprogramming’ is one of the hallmarks of the myocardial infarction (MI), where cardiomyocytes shift from fatty acid oxidation to anaerobic glycolysis to meet energy demands, producing lactate. Very few studies suggest a positive correlation between increased lactate levels and mortality in heart failure patients, implying the importance of lactylation in the pathogenesis of MI. However, knowledge of lactylation post-MI is currently limited. The project aims to understand the differences in mitochondrial lactylated proteins and their relevance in the progression or restoration of MI pathogenesis. We also utilize AZD3965, a selective inhibitor of monocarboxylate transporter 1, which is responsible for bidirectional transport of lactate, to understand the lactylation profiling in MI. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-06-08 |
| AnnouncementXML | Submission_2026-06-07_16:23:39.695.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Hadi Pourhadi |
| SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090; |
| ModificationList | lactic acid |
| Instrument | Orbitrap Eclipse |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-09-04 12:06:26 | ID requested | |
| ⏵ 1 | 2026-06-07 16:23:40 | announced | |
Publication List
| Kadam A, Kashyap S, Samantaray K, Jaiswal N, Goyani S, Kramer PA, Hadi P, Lee J, Furdui CM, Jadiya P, Tomar D, Lactylation landscape of mitochondrial proteins in myocardial infarction. Redox Biol, 94():104226(2026) [pubmed] |
| 10.1016/j.redox.2026.104226; |
Keyword List
| submitter keyword: Lactate, MCT1, Lactylation |
| Mitochondria |
| Myocardial Infarction |
| AZD3965 |
Contact List
| Dhanendra Tomar |
|---|
| contact affiliation | PhD, Assistant Professor, Department of Cardiovascular Medicine, Wake Forest University School of Medicine |
| contact email | Dhanendra.tomar@wfusm.edu |
| lab head | |
| Hadi Pourhadi |
|---|
| contact affiliation | Proteomics and Metabolomics Shared Resource (PMSR), Wake Forest University School of Medicine |
| contact email | hpourhad@wakehealth.edu |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD068087 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD068087
- Label: PRIDE project
- Name: Mitochondrial protein lactylation in myocardial infarction
