PXD068083 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | A short SUMOylation tag modulates transcription factor activity |
| Description | This research demonstrates that a short peptide, composed of residues 24-55 of ZNF451, is sufficient to induce SUMOylation of target proteins, both in vitro and in human cells. Increased SUMOylation of the transcription factor p53 via fusion with the ZNF451 peptide inhibits its transcriptional activity, providing a proof of principle that targeted SUMOylation can be used to modulate the activity of targeted transcription factors. |
| HostingRepository | PRIDE |
| AnnounceDate | 2025-12-01 |
| AnnouncementXML | Submission_2025-11-30_16:12:25.847.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Chongyang Li |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | phosphorylated residue; sumoylated lysine; monohydroxylated residue; deamidated residue; iodoacetamide derivatized residue |
| Instrument | Orbitrap Exploris 480; Orbitrap Ascend |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-09-04 10:42:17 | ID requested | |
| ⏵ 1 | 2025-11-30 16:12:26 | announced | |
Publication List
| Bouchard AY, Vivet AJI, Cabana VC, Li C, Thibault P, Lussier MP, Mader S, Cappadocia L, A short SUMOylation tag modulates transcription factor activity. J Biol Chem, 301(11):110807(2025) [pubmed] |
| 10.1016/j.jbc.2025.110807; |
Keyword List
| submitter keyword: SUMO E3 ligase, small ubiquitin-like modifier (SUMO), transcription factor, SUMOylation tag, ZNF451,SUMOylation, p53 |
Contact List
| Pierre Thibault |
|---|
| contact affiliation | 1 Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, Canada 2 Department of Chemistry, Université de Montréal, Montréal, Canada |
| contact email | pierre.thibault@umontreal.ca |
| lab head | |
| Chongyang Li |
|---|
| contact affiliation | Institute for Research In Immunology and Cancer, University of Montreal |
| contact email | chongyang.li@umontreal.ca |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/12/PXD068083 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD068083
- Label: PRIDE project
- Name: A short SUMOylation tag modulates transcription factor activity
