PXD068068

PXD068068 is an original dataset announced via ProteomeXchange.

Title	Proteomic analysis of platelets isolated from mice deficient for IL-33 or treated with recombinant IL-33
Description	Platelets, traditionally recognized for their involvement in hemostasis and wound healing, also play a central role in immune regulation and inflammation. Their function and production adapt in response to inflammatory cues such as cytokines and danger-associated molecular patterns. Interleukin-33 (IL-33), an alarmin released during tissue damage, particularly in lung inflammation, has been implicated in influencing platelet biology, though its exact effects remain poorly understood. To clarify IL-33’s role, we examined its impact on platelet proteome. We first compared the proteome of platelets purified by FACS from IL-33-deficient (IL-33KO) mice versus WT mice (n=5 biological replicates in each group, 10 raw MS files). We also compared the proteome of platelets from WT mice which were either non stimulated (n= 8 biological replicates) or treated intranasally with recombinant IL-33 (n= 9 biological replicates).
HostingRepository	PRIDE
AnnounceDate	2026-04-27
AnnouncementXML	Submission_2026-04-26_19:31:51.811.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Anne Gonzalez de Peredo
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	timsTOF SCP

Revision	Datetime	Status	ChangeLog Entry
0	2025-09-04 08:01:36	ID requested
⏵ 1	2026-04-26 19:31:52	announced

10.1182/bloodadvances.2025018363;

Gelon L, Roga S, Gonzalez-de-Peredo A, Vidal E, Girard JP, Severin S, Lefran, ç, ais E, The alarmin interleukin-33 modulates platelet proteome, function, and biogenesis. Blood Adv, 10(7):2333-2348(2026) [pubmed]

submitter keyword: Interleukin-33, global proteome,Platelets, allergy

Odile Schiltz
contact affiliation	Institute of Pharmacology and Structural Biology, CNRS, Toulouse, France
contact email	gonzalez@ipbs.fr
lab head
Anne Gonzalez de Peredo
contact affiliation	CNRS/IPBS
contact email	gonzalez@ipbs.fr
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD068068

PRIDE project URI

• PRIDE
  1. PXD068068
     1. Label: PRIDE project
     2. Name: Proteomic analysis of platelets isolated from mice deficient for IL-33 or treated with recombinant IL-33