PXD068051

PXD068051 is an original dataset announced via ProteomeXchange.

Title	Metabolomics of red blood cells
Description	Red blood cells (RBCs) play a vital role in adaptations to hypoxia at high altitude, however, metabolic alternations of RBCs under long-term hypoxia remain unknown. Method: Here, we employed the broad- and energy-targeted metabolism approaches to study the differences in the RBCs of lowlanders living in plain area and acclimated to plateau for more than 10 years, and adaptive plateau highlanders. Compared with plain individuals, the glycolytic flux remained stable in acclimated and adaped subjects, and purine metabolism was not correspondingly increased. Notably, the oxidative pentose phosphate pathway was reduced in the RBCs of acclimated and adapted sub-jects. The consistency loss was observed in the reduced glutathione, a key metabolite of the red blood cell redox system. The adaptive enhancement of glutamate amidation may indirectly contribute to the decrease in reduced glutathione. Further, reduced superoxide dismutase activity and enhanced catalase activity confirmed a distinct al-teration in the antioxidant enzyme system of RBCs under long-term hypoxic. Metab-olomics and clinical measurements support the view that RBCs undergo lower oxida-tive stress under hypoxia, offering new insights into the hypoxic adaptations.
HostingRepository	iProX
AnnounceDate	2025-09-04
AnnouncementXML	Submission_2025-09-04_02:40:49.809.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Maoshan Chen
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	QTRAP 6500+

Revision	Datetime	Status	ChangeLog Entry
0	2025-09-04 02:34:58	ID requested
⏵ 1	2025-09-04 02:40:50	announced

Dataset with its publication pending

submitter keyword: Erythrocytes, high altitude

Zhongjun Li
contact affiliation	The Second Affiliated Hospital of Army Medical University
contact email	zhongjunli@tmmu.edu.cn
lab head
Maoshan Chen
contact affiliation	Army Medical University
contact email	maoshanchen@tmmu.edu.cn
dataset submitter

iProX dataset URI