PXD068046
PXD068046 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Proteomic Analysis of PD-1 Resistance in MSI-H Colorectal Cancer Using Data-Independent Acquisition (DIA) Mass Spectrometry |
| Description | This dataset contains quantitative proteomics data obtained from a mouse model of PD-1 resistance in microsatellite instability-high (MSI-H) colorectal cancer. Using Data-Independent Acquisition (DIA) mass spectrometry, protein samples were analyzed to identify differentially expressed proteins between PD-1-sensitive and PD-1-resistant tumor samples. The data were acquired using high-resolution mass spectrometry on a Thermo Scientific Orbitrap instrument, followed by protein identification and label-free quantification (LFQ) using DIA-NN software. The dataset includes protein identification and quantification results from various tumor samples, with a focus on identifying key proteins involved in immune evasion mechanisms that contribute to resistance to αPD-1 immunotherapy. Differential protein expression analysis revealed several proteins that are significantly upregulated or downregulated in PD-1-resistant tumors, which may serve as potential biomarkers or therapeutic targets. |
| HostingRepository | iProX |
| AnnounceDate | 2025-09-04 |
| AnnouncementXML | Submission_2025-09-04_02:25:54.729.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Zhijian Zheng |
| SpeciesList | scientific name: Mus musculus; NCBI TaxID: 10090; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Astral |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2025-09-04 02:25:39 | ID requested | |
| ⏵ 1 | 2025-09-04 02:25:55 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: MSI-H colorectal cancer |
| αPD-1 resistance; |
Contact List
| Jianfei Fu | |
|---|---|
| contact affiliation | Affiliated Jinhua Hospital, Zhejiang University School of Medicine |
| contact email | fujianfei@zju.edu.cn |
| lab head | |
| Zhijian Zheng | |
| contact affiliation | Affiliated Jinhua Hospital, Zhejiang University School of Medicine |
| contact email | zhengzhijian337@163.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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