PXD067971 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Epigenetic resetting in the Parkinson's disease entail histone modification remodeling. |
| Description | Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by the loss of dopaminergic neurons (DN) in the substantia nigra and disrupted cellular maintenance. Here, we demonstrate that NDST3-mediated epigenetic reprogramming halts neuronal degeneration and restores motor function in a PD animal model. Following NDST3 administration, DN and associated circuits in the substantia nigra and striatum show marked revitalization, accompanied by significant alleviation of PD-like motor deficits. Integrative single-cell and spatial RNA sequencing with ChIP sequencing reveal that NDST3-driven reactivation of pathways linked to neuronal survival, synaptic integrity, steering compromised cells toward a resilient phenotype. By recalibrating the epigenetic landscape, NDST3 fosters cellular maintenance and functional recovery within key motor circuits. These findings highlight NDST3’s therapeutic potential as epigenetic modulator in PD. Our findings provide insights into the mechanisms underlying neuronal revitalization and underscore the promise of NDST3 as a novel agent for restoring brain function in neurodegenerative conditions. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-03-16 |
| AnnouncementXML | Submission_2026-03-16_05:12:07.850.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Yongwoo Na |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Eclipse |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-09-02 01:44:47 | ID requested | |
| ⏵ 1 | 2026-03-16 05:12:08 | announced | |
Publication List
| 10.1002/advs.202507323; |
| Chang Y, Na Y, Im H, Yang G, Yang S, Shim HS, Kim C, Kim G, Park HJ, Kim HY, Lee SE, Lee W, Ha Y, Park S, Kim J, Cho WY, Sun W, Kim JS, Yoo J, NDST3-Induced Epigenetic Reprogramming Reverses Neurodegeneration in Parkinson's Disease. Adv Sci (Weinh), 13(14):e07323(2026) [pubmed] |
Keyword List
| submitter keyword: Human, TMT, Parkinson's, organoid, LC-MS/MS |
Contact List
| Jong-Seo Kim |
|---|
| contact affiliation | Center for RNA Research, Institute for Basic Science, Seoul 08826, S. Korea School of Biological Sciences, Seoul National University, Seoul 08826, S. Korea |
| contact email | jongseokim@snu.ac.kr |
| lab head | |
| Yongwoo Na |
|---|
| contact affiliation | Seoul National University |
| contact email | nyw1412@snu.ac.kr |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/03/PXD067971 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD067971
- Label: PRIDE project
- Name: Epigenetic resetting in the Parkinson's disease entail histone modification remodeling.
