PXD067886 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Global proteomic determination of the poly-pharmacological effects of PARP inhibitors following treatment of high-grade serous ovarian cancer cells |
| Description | Global proteome perturbations upon PARPi treatment were measured using quantitative mass spectrometry-based proteomics. High-grade serous ovarian cancer (HGSOC) cell lines (PEO1, Caov3, and COV362) were treated with IC50 dose concentrations of Olaparib, Niraparib, and Rucaparub to assess differences in proteome response to differing PARPi accross a HGSOC cell line panel. |
| HostingRepository | PRIDE |
| AnnounceDate | 2025-12-30 |
| AnnouncementXML | Submission_2025-12-30_12:54:30.091.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Stefani Thomas |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Q Exactive Plus |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-08-29 13:55:57 | ID requested | |
| ⏵ 1 | 2025-12-30 12:54:30 | announced | |
Publication List
Keyword List
| submitter keyword: High-grade serous ovarian cancer (HGSOC), proteomics, mass spectrometry, PARP inhibitors (PARPi) |
Contact List
| Stefani N. Thomas |
|---|
| contact affiliation | Department of Laboratory Medicine and Pathology, University of Minnesota School of Medicine, Minneapolis, Minnesota 55455, USA |
| contact email | stefanit@umn.edu |
| lab head | |
| Stefani Thomas |
|---|
| contact affiliation | University of Minnesota |
| contact email | stefanit@umn.edu |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/12/PXD067886 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD067886
- Label: PRIDE project
- Name: Global proteomic determination of the poly-pharmacological effects of PARP inhibitors following treatment of high-grade serous ovarian cancer cells
