PXD067837

PXD067837 is an original dataset announced via ProteomeXchange.

Title	NATCANCER-A16341B 1 2 iNV GOV 3 4GOV
Description	Oncolytic viruses (OVs) are replication-competent viruses that selectively infect tumor cells and induce anti-tumor responses. However, systemic delivery is limited by neutralizing antibodies and poor intratumoral bioavailability. We developed iNV-GOV, a tumor-targeted, low-immunogenic platform that cloaks OVs with genetically engineered, immune-compatible cell membranes expressing a chimeric antigen receptor, shielding virions from immune recognition and guiding them to tumors. The payload encodes an N-terminal gasdermin under a heat-shock promoter, and ultrasound-induced mild hyperthermia drives gasdermin expression, triggering tumor-cell pyroptosis, enabling accelerated oncolysis and rapid release of OVs from lysed tumor cells which subsequently infect neighboring tumor cell populations. After systemic administration, iNV-GOV efficiently targets and infects humanized orthotopic patient-derived xenografted tumors, ultrasound activation induces pyroptosis and elicits robust antitumor immunity. Thus, the systemically injectable, tumor-targeted OVs that are capable of rapid and continuous infection of tumor cells represent a promising oncolytic virotherapy for treating a wide range of cancers.
HostingRepository	PRIDE
AnnounceDate	2025-10-03
AnnouncementXML	Submission_2025-10-03_06:20:06.199.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Minqi Yang
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Exploris 480

Revision	Datetime	Status	ChangeLog Entry
0	2025-08-28 07:17:51	ID requested
⏵ 1	2025-10-03 06:20:06	announced

Dataset with its publication pending

submitter keyword: iNV GOV and GOV

Minqi Yang
contact affiliation	Zhejiang University
contact email	yangminqi1999@163.com
lab head
Minqi Yang
contact affiliation	Zhejiang University
contact email	yangminqi1999@163.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/10/PXD067837

PRIDE project URI

• PRIDE
  1. PXD067837
     1. Label: PRIDE project
     2. Name: NATCANCER-A16341B 1 2 iNV GOV 3 4GOV