PXD067755

PXD067755 is an original dataset announced via ProteomeXchange.

Title	Lactylomics for mouse MCAO/R cortex tissue
Description	Mice were anesthetized with 2% isoflurane (RWD, China), and a midline cervical incision was made to expose the left common carotid artery (CCA), external carotid artery (ECA), and internal carotid artery (ICA). The CCA was ligated distally, and two ligatures were placed on the ECA, one at its distal end and the other at the ECA-ICA bifurcation. A silicon-coated filament (RWD, China) was inserted into the ICA through a small incision in the ECA to occlude the middle cerebral artery. After 2 hours, the filament was removed to initiate reperfusion. Rectal temperature was maintained at 37°C throughout surgery. Sham-operated mice underwent identical procedures without filament insertion.
HostingRepository	PRIDE
AnnounceDate	2026-09-07
AnnouncementXML	Submission_2026-09-06_16:17:10.352.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Haipeng Wang
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090;
ModificationList	lactic acid
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2025-08-26 10:34:46	ID requested
⏵ 1	2026-09-06 16:17:11	announced

10.1002/advs.202516663;

Duan C, Zhang R, Ding S, Feng Y, Shen T, Wang Z, Bao W, Shui K, Qin J, Chen J, Zhang M, Ren Z, Zhao D, Guo X, Ai Z, Yang X, Zhou P, Dong Z, Phosphorylation-Facilitated CKB Lactylation At K11 By GCN5 Enhances Creatine Kinase Activity and Mitigates Neuronal Damage After Cerebral Ischemia-Reperfusion. Adv Sci (Weinh), ():e16663(2026) [pubmed]

submitter keyword: ischemic stroke, reperfusion injury, MCAO/R,Lactylation, LC-MS/MS

Chao Duan
contact affiliation	Hubei University of Medicine, Taihe Hospital
contact email	duanchao0803@163.com
lab head
Haipeng Wang
contact affiliation	Huazhong agricultural university
contact email	10115@webmail.hzau.edu.cn
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/09/PXD067755

PRIDE project URI

• PRIDE
  1. PXD067755
     1. Label: PRIDE project
     2. Name: Lactylomics for mouse MCAO/R cortex tissue