PXD067743

PXD067743 is an original dataset announced via ProteomeXchange.

Title	Extracellular vesicle‑mediated restraint of hepatic CD74–NF‑κB repairs diabetic neuropathy
Description	Diabetic peripheral neuropathy (DPN) is a common and devastating complication of diabetes mellitus, leading to progressive degeneration of peripheral nerves and resulting in chronic pain, sensory loss, and disability. Despite its high prevalence and significant burden, current treatments are largely palliative, as the multifaceted metabolic, inflammatory, and vascular mechanisms that underlie DPN have proven challenging to target with disease-modifying therapies. Extracellular vesicles (EVs, including exosomes) are increasingly recognized for their capacity to mediate intercellular communication and promote tissue repair in various disease contexts. While previous studies have suggested the therapeutic potential of EVs on DPN, the systemic fate of administered EVs and the mechanisms by which they orchestrate repair multiorgan systems remain unclear. Mesenchymal stromal/stem cells (MSCs) are notable for their immunoregulatory properties, making them an attractive and practical source of EVs for translational research. Here, we investigate the action and mechanism of therapeutic EVs derived from MSCs in a mouse model of DPN. Using in vivo imaging, multi-omics analyses, and functional assessments, we define how liver-trophic EVs elicit cross-organ immunomodulation and promote neural repair in diabetic mice.
HostingRepository	PRIDE
AnnounceDate	2026-07-27
AnnouncementXML	Submission_2026-07-27_01:59:38.466.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Qianfa Long
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Exploris 480

Revision	Datetime	Status	ChangeLog Entry
0	2025-08-26 06:29:33	ID requested
⏵ 1	2026-07-27 01:59:39	announced

Dataset with its publication pending

submitter keyword: Extracellular Vesicles；Diabetic peripheral neuropathy

qianfa Long
contact affiliation	Xi'an Central Hospital
contact email	lonva@live.cn
lab head
Qianfa Long
contact affiliation	Xi’an Central Hospital, Xi’an Jiaotong University
contact email	lonva@live.cn
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/07/PXD067743

PRIDE project URI

• PRIDE
  1. PXD067743
     1. Label: PRIDE project
     2. Name: Extracellular vesicle‑mediated restraint of hepatic CD74–NF‑κB repairs diabetic neuropathy