⮝ Full datasets listing
PXD067722
PXD067722 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Nectin-4 is an entry receptor for rubella virus |
| Description | Rubella virus (RuV) causes rubella and, through maternal infection during pregnancy, congenital rubella syndrome (CRS). Despite its clinical significance, the cellular entry mechanism of RuV remains poorly understood due to limited identification of host receptors, impeding pathogenesis research and therapeutic development. Here we show that Nectin-4 acts as the primary RuV cellular receptor using proximity biotin labeling-based proteomics and CRISPR/Cas9 screening. This receptor is shared with measles virus, indicating convergent evolution in viral entry. Nectin-4 directly binds RuV via its ectodomain, mediating calcium-independent viral attachment and endocytic internalization. In respiratory epithelial cells, Nectin-4 enables basolateral RuV entry with apical progeny release. Using human placental organoid models, we identified syncytiotrophoblasts as initial RuV infection targets, with infection significantly reduced upon Nectin-4 inhibition. These findings establish Nectin-4 as critical for both respiratory transmission and maternal-fetal vertical transmission of RuV. Our results provide key insights into RuV pathogenesis and identify Nectin-4 as a potential therapeutic target for CRS prevention. Importantly, the shared receptor usage with measles virus enables integrated approaches for eliminating both rubella and measles. |
| HostingRepository | jPOST |
| AnnounceDate | 2026-08-17 |
| AnnouncementXML | Submission_2026-08-17_01:37:42.114.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Non peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Yayoi Kimura |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
| ModificationList | unknown modification; L-methionine sulfoxide; S-carboxamidomethyl-L-cysteine; alpha-aminocarbamoylated residue; Acetyl |
| Instrument | LTQ Orbitrap Elite |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2025-08-25 20:54:46 | ID requested | |
| ⏵ 1 | 2026-08-17 01:37:42 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: rubella virus, receptor, proxymal biotin-labeling |
Contact List
| Yoshio Mori | |
|---|---|
| lab head | |
| Yayoi Kimura | |
| contact affiliation | Yokohama City University |
| dataset submitter | |
Full Dataset Link List
| jPOST dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.jpostdb.org/JPST004036/ |
