PXD067717

PXD067717 is an original dataset announced via ProteomeXchange.

Title	Therapeutic potential of hUC-MSCs in Alzheimer's Disease: linking neuropathological improvements with proteomics and microbiome insights
Description	Alzheimer's disease (AD) is defined neuropathologically by the abnormal accumulation of aggregated amyloid-beta (Aβ) peptides and tau that form extracellular and intracellular amyloid deposits, respectively. Inherited forms of AD (familial AD, FAD) are caused by autosomal dominant mutations in the amyloid precursor protein (APP) and presenilin (PSEN1 and PSEN2) genes. AD is marked by severe neuronal degeneration and depletion, primarily resulting from the overproduction of senile plaques composed of Aβ and the accumulation of hyperphosphorylated microtubule-associated protein tau (P-Tau) deposits. As the global population ages, the incidence of AD is increasing, placing a growing burden on societies and families. Current treatments for AD primarily offer symptomatic relief but fail to halt or reverse the disease's progression. Therefore, exploring novel therapeutic strategies is of paramount importance.
HostingRepository	iProX
AnnounceDate	2025-08-25
AnnouncementXML	Submission_2025-08-25_19:09:03.287.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jiayi Zhang
SpeciesList	scientific name: Rattus rattus; NCBI TaxID: 10117;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2025-08-25 19:06:34	ID requested
⏵ 1	2025-08-25 19:09:03	announced

Dataset with its publication pending

submitter keyword: Alzheimer's disease, Stem cell therapy, Umbilical cord mesenchymal stem cells, Proteomics, 16S rDNA, Molecular mechanism

Xifu Liu
contact affiliation	Hebei Normal University
contact email	xfliu@hebtu.edu.cn
lab head
Jiayi Zhang
contact affiliation	Hebei Normal University
contact email	zhangjiayi0218@163.com
dataset submitter

iProX dataset URI