PXD067654

PXD067654 is an original dataset announced via ProteomeXchange.

Title	Oligosaccharyltransferase is involved in targeting to ER-associated degradation
Description	The majority of secretory proteins undergo N-glycosylation, a process catalyzed by oligosaccharyltransferase (OST), a membrane-bound protein complex that associates with the translocation channels within the endoplasmic reticulum (ER). Proteins failing quality control undergo ER-associated degradation (ERAD) by retrotranslocation to cytosolic proteasomes. Using a misfolded protein bait and SILAC proteomics, we unexpectedly identified several OST subunits among top hits. For further details, Please refer to the publication "Oligosaccharyltransferase is involved in targeting to ER-associated degradation" by Marina Shenkman et al..
HostingRepository	PRIDE
AnnounceDate	2025-10-14
AnnouncementXML	Submission_2025-10-14_06:43:05.182.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Roman Körner
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	iodoacetamide derivatized residue
Instrument	LTQ FT; LTQ Orbitrap

Revision	Datetime	Status	ChangeLog Entry
0	2025-08-24 02:00:03	ID requested
⏵ 1	2025-10-14 06:43:05	announced

10.3390/CELLS14201593;

submitter keyword: Oligosaccharyltransferase,ER-associated degradation, protein quality control, protein--folding

Gerardo Z. Lederkremer
contact affiliation	The Shmunis School of Biomedicine and Cancer Research, Cell Biology Division, George Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel
contact email	gerardol@tauex.tau.ac.il
lab head
Roman Körner
contact affiliation	Max-Planck Institute of Biochemistry, Department of Cellular Biochemistry
contact email	rkoerner@biochem.mpg.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/10/PXD067654

PRIDE project URI

• PRIDE
  1. PXD067654
     1. Label: PRIDE project
     2. Name: Oligosaccharyltransferase is involved in targeting to ER-associated degradation