PXD067605 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Mitochondrial CircRNA CircMT-RNR2 Safeguards Antioxidant Defense to Support Fibroblast Functions in Wound Repair |
| Description | Diabetic foot ulcers (DFUs) are a debilitating diabetes complication in which mitochondrial dysfunction and oxidative stress are prominent but mechanistically unresolved features. Here, we identify the mitochondria-encoded circular RNA circMT-RNR2 as a novel modulator of mitochondrial redox homeostasis in human skin wound healing. CircMT-RNR2 is reduced in DFU patient tissue and diabetic mouse wounds, enriched in dermal fibroblasts, and localized to mitochondria. Its loss impairs fibroblast proliferation, migration, extracellular matrix production, and contraction by destabilizing the mitochondrial antioxidant protein PRDX3, leading to elevated oxidative stress, mitochondrial damage, and mitophagy. In murine and human ex vivo wound models, circMT-RNR2 knockdown delays healing, whereas overexpression accelerates repair and boosts antioxidant defenses. These findings position circMT-RNR2 as a mitochondrial guardian of skin healing and a promising therapeutic target for DFUs. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-06-08 |
| AnnouncementXML | Submission_2026-06-07_16:33:56.505.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Ning Xu Landén |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | iodoacetamide derivatized residue |
| Instrument | LTQ Orbitrap |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-08-22 07:17:49 | ID requested | |
| ⏵ 1 | 2026-06-07 16:33:57 | announced | |
Publication List
| 10.1002/advs.202517141; |
| Niu G, Geara J, Chen Y, Luo L, Xiao Y, Liu Z, Gaborieau M, Pan L, Loh E, Li D, Sommar P, Wang A, Zheng X, Xu Land, é, n N, Mitochondrial CircRNA CircMT-RNR2 Safeguards Antioxidant Defense to Support Fibroblast Functions in Wound Repair. Adv Sci (Weinh), 13(26):e17141(2026) [pubmed] |
Keyword List
| submitter keyword: wound repair, diabetic foot ulcers,Mitochondrial circRNA |
Contact List
| Ning Xu Landén |
|---|
| contact affiliation | Dermatology and Venereology Division, Department of Medicine (Solna), Center for Molecular Medicine, Karolinska Institute, Stockholm, Sweden |
| contact email | ning.xu@ki.se |
| lab head | |
| Ning Xu Landén |
|---|
| contact affiliation | Karolinska Institutet |
| contact email | ning.xu@ki.se |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
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| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD067605
- Label: PRIDE project
- Name: Mitochondrial CircRNA CircMT-RNR2 Safeguards Antioxidant Defense to Support Fibroblast Functions in Wound Repair
