PXD067589

PXD067589 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	exosome exoWNT3A/RSPO1 mass spectrum data
Description	dual-ligand-carrying exosome (exoWNT3A/RSPO1) hyperactivated the WNT signaling and promoted efficient hepatic organoid growth compared to the small molecule inhibitor CHIR99021. Importantly, the exosome can be efficiently delivered for robust WNT signaling activation in the liver. Remarkably, exoWNT3A/RSPO1 could accelerate liver repair and regeneration under various conditions, including acute and chronic injuries and aging-associated phenotypes. Collectively, our work revealed the broad therapeutic effects of WNT signaling activation in the liver through the dual-ligand-carrying exosomes.
HostingRepository	PRIDE
AnnounceDate	2025-10-10
AnnouncementXML	Submission_2025-10-10_05:18:34.163.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Shixiang Wang
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Astral

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2025-08-21 20:09:57	ID requested
⏵ 1	2025-10-10 05:18:34	announced

Publication List

10.1038/S41467-025-64069-8;

10.1038/S41467-025-64069-8;

Keyword List

submitter keyword: WNT3A, RSPO1, MS,exosome

submitter keyword: WNT3A, RSPO1, MS,exosome

Contact List

Yun-Shen Chan
contact affiliation	Guangzhou National Laboratory, No.9 Xing Dao Huan Bei Road, Guangzhou International Bio Island, Guangzhou 510005, Guangdong Province, China
contact email	chan_yunshen@gzlab.ac.cn
lab head
Shixiang Wang
contact affiliation	Guangzhou national labratory
contact email	wangsx235@gmail.com
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/10/PXD067589
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/10/PXD067589

PRIDE project URI

Repository Record List

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