PXD067573

PXD067573 is an original dataset announced via ProteomeXchange.

Title	Mass spectrometry-based phosphoproteomics of PCMD-1
Description	PCMD-1 is a centriolar protein that stabilizes the pericentriolar material (PCM) scaffold in C. elegans. Our data show that CDK-1 primes PCMD-1 for PLK-1–dependent phosphorylation. Mutations in PLK-1 docking sites reduce PCMD-1 phosphorylation, leading to disorganized PCM, unstable centrosomes, and delayed centriole separation. These findings suggest that PCMD-1 phosphorylation is essential for tethering and maintaining PCM scaffold integrity during mitosis.
HostingRepository	PRIDE
AnnounceDate	2025-10-24
AnnouncementXML	Submission_2025-10-24_00:34:21.741.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Serena Schwenkert
SpeciesList	scientific name: Caenorhabditis elegans; NCBI TaxID: NEWT:6239;
ModificationList	phosphorylated residue
Instrument	timsTOF HT

Revision	Datetime	Status	ChangeLog Entry
0	2025-08-21 07:59:13	ID requested
⏵ 1	2025-10-24 00:34:22	announced

Dataset with its publication pending

submitter keyword: C. elegans

Serena Schwenkert
contact affiliation	MSBioLMU Großhaderner Str. 2-4 82152 Planegg-Martinsried
contact email	serena.schwenkert@lmu.de
lab head
Serena Schwenkert
contact affiliation	LMU Munich
contact email	serena.schwenkert@lmu.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/10/PXD067573

PRIDE project URI

• PRIDE
  1. PXD067573
     1. Label: PRIDE project
     2. Name: Mass spectrometry-based phosphoproteomics of PCMD-1