PXD067541

PXD067541 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Proteomic analysis of Fosinopril-induced effects in A549 human lung adenocarcinoma cells
Description	This project contains the quantitative proteomics data from a study investigating the effects of fosinopril on human lung adenocarcinoma cells. A549 cell lines were treated with 90 μM fosinopril or vehicle control for 24 days. Proteins were digested and analyzed by LC-MS/MS to identify and quantify differentially expressed proteins, aiming to reveal the drug's mechanisms of action and potential therapeutic targets.
HostingRepository	PRIDE
AnnounceDate	2025-12-01
AnnouncementXML	Submission_2025-11-30_16:13:51.527.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yue Gao
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2025-08-21 04:50:59	ID requested
⏵ 1	2025-11-30 16:13:52	announced

Publication List

Gao Y, Zhai X, Zhang C, Zhao H, Ji B, Sun R, Du X, Du Y, Gao S, Zhang Y, Wang T, Fosinopril mediates antitumor efficacy by inducing GSDME-dependent pyroptosis in NSCLC. Cell Death Discov, 11(1):540(2025) [pubmed]
10.1038/s41420-025-02791-4;

Gao Y, Zhai X, Zhang C, Zhao H, Ji B, Sun R, Du X, Du Y, Gao S, Zhang Y, Wang T, Fosinopril mediates antitumor efficacy by inducing GSDME-dependent pyroptosis in NSCLC. Cell Death Discov, 11(1):540(2025) [pubmed]

10.1038/s41420-025-02791-4;

Keyword List

submitter keyword: fosinopril
A549
NSCLC

submitter keyword: fosinopril

A549

NSCLC

Contact List

Tao Wang
contact affiliation	Binzhou Medical University Hospital
contact email	wangtaoliwang@163.com
lab head
Yue Gao
contact affiliation	Binzhou Medical University Hospital
contact email	gaoyue1014001@163.com
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/12/PXD067541
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/12/PXD067541

PRIDE project URI

Repository Record List

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