PXD067518

PXD067518 is an original dataset announced via ProteomeXchange.

Title	Non-modified Molecules Strategy Enable Proteome-Wide Mapping of Catechol Derivatives Interactome
Description	Here, we presented a modification-free strategy termed oxidative addition-boronate affinity enrichment (OABA), that leverages catechol oxidation to ortho-quinones for covalent capture of nucleophilic protein residues, followed by chemoselective enrichment via boronate affin-ity. This redox-enabled approach preserves native structure-activity relationships while enabling direct mapping of catechol-protein interactomes.
HostingRepository	iProX
AnnounceDate	2025-08-16
AnnouncementXML	Submission_2025-08-19_23:59:48.874.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Zichun Qiao
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2025-08-19 23:59:00	ID requested
⏵ 1	2025-08-19 23:59:49	announced

Dataset with its publication pending

submitter keyword: modification-free, catechol derivatives, interactome profiling

Lihua Zhang
contact affiliation	State Key Laboratory of Medical Proteomics, National Chromatographic R. & A. Center, CAS Key Laboratory of Separa-tion Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences
contact email	lihuazhang@dicp.ac.cn
lab head
Zichun Qiao
contact affiliation	State Key Laboratory of Medical Proteomics, National Chromatographic R. & A. Center, CAS Key Laboratory of Separa-tion Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences
contact email	zichun_q@163.com
dataset submitter

iProX dataset URI