⮝ Full datasets listing
PXD067514
PXD067514 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Proteomic profiling of human omental and subcutaneous adipose tissue in individuals with a broad range of BMI |
| Description | Obesity is a major public health challenge affecting an ever-increasing proportion of the global population. It is associated with numerous comorbidities. Progressive expansion and remodeling of adipose tissue may lead to depot specific changes in adipose tissue biology and energy partitioning. Such changes likely precede the development of obesity-related complications. To facilitate a deeper understanding of adipose tissue biology, a comprehensive quantitative proteomic dataset is presented at the peptide and protein level. Data-independent acquisition LC-MS/MS data were acquired from matched subcutaneous and omental adipose tissues from metabolically healthy individuals with no comorbidities and covering a wide range of body mass indexes. Adipose tissue samples were collected during elective surgeries and immediately processed for histology or frozen until proteomic analysis. Internal and external quality control systems ensured high quality data. All data presented are available via ProteomeXchange. This dataset will allow new insights into biological changes that evolve with increasing adiposity captured before the onset of comorbidities. Matched sampling across fat depots provides an opportunity to uncover depot-specific physiological signatures. |
| HostingRepository | PanoramaPublic |
| AnnounceDate | 2026-03-07 |
| AnnouncementXML | Submission_2026-03-07_10:24:13.461.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Supported dataset by repository |
| PrimarySubmitter | Alex Zelter |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | Carbamidomethyl; Label:13C(6)15N(2); Label:13C(6)15N(4) |
| Instrument | Orbitrap Exploris 480 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2025-08-19 21:21:50 | ID requested | |
| 1 | 2026-01-18 13:04:22 | announced | |
| 2 | 2026-02-13 09:55:37 | announced | : Metadata update |
| ⏵ 3 | 2026-03-07 10:24:14 | announced | : Added PubMed ID |
Publication List
| Zelter A, Wen YW, Riffle M, Czuba LC, Yadav AS, Zhu J, Snyder JM, Maurais A, LaFrance J, Khandelwal S, Chen JY, Williams E, Parr Z, Kim D, Rubinow KB, MacCoss MJ, Isoherranen N, Proteomic profiling of human omental and subcutaneous adipose tissue in individuals with a broad range of BMI. Sci Data, ():(2026) [pubmed] |
Keyword List
| submitter keyword: Obesity, comorbidities, BMI, adipose, LC-MS/MS, subcutaneous, omental, quantitative proteomics, DIA mass spectrometry |
Contact List
| Nina Isoherranen | |
|---|---|
| contact affiliation | Department of Pharmaceutics University of Washington, School of Pharmacy |
| contact email | ni2@uw.edu |
| lab head | |
| Alex Zelter | |
| contact affiliation | Department of Genome Sciences, University of Washington |
| contact email | azelter@uw.edu |
| dataset submitter | |
Full Dataset Link List
| Panorama Public dataset URI |
