PXD067460 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | In-Depth Platelet Proteomic Analysis in Various Dementia Stages: Unveiling Biomarkers for Alzheimer's Disease |
| Description | Early detection of Alzheimer’s disease (AD) can provide an effective scheme to prevent the disease progression. Studies have shown that blood platelets are a useful peripheral source for AD diagnosis. Identifying proteomics-based platelet biomarkers of mild cognitive impairment (MCI) and AD related to amyloid peptide (A) deposition, which remains largely unexplored, is valuable. This study compared four groups from 18 human participants. subjective memory impairment (SMI, n = 4) as cognitive normal control, MCI without A deposition (MCI-A(), n = 5), MCI with A deposition (MCI-A(), n = 5), and AD (n = 4). We performed in-depth platelet protein profiling using high-throughput LC–MS/MS with tandem mass tag (TMT) labeling.MCI-A(), MCI-A(), and AD in comparison to SMI. Hierarchical clustering analysis revealed seven different patterns of proteomic alterations among functional network and gene ontology (GO) enrichment showed a distinct feature of each cluster specific processes such as platelet activation, AD, and apoptotic signaling pathways. In particular, our data indicated that upregulated proteins in MCI-A() and AD are associated with endomembrane system organization. Moreover, we determined the relative abundance of multiple protein candidates that significantly changed in MCI-A() and AD compared to SMI and MCI-A(). Our data demonstrated that several platelet proteins, including ATP6V0C, AP4B1, RAB2B, PSMD9, FKBP1B, and mTOR, can be key molecular targets for predicting AD at the stage of MCI with A deposition and provide insights into amyloid-related neurodegeneration. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-05-25 |
| AnnouncementXML | Submission_2026-05-24_19:03:33.520.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Andrew Kim |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | monohydroxylated residue; iodoacetamide derivatized residue |
| Instrument | Q Exactive |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-08-18 03:32:49 | ID requested | |
| ⏵ 1 | 2026-05-24 19:03:34 | announced | |
Publication List
| 10.1186/s13041-026-01294-2; |
| Cho YE, Kim A, Lee HM, Oh JW, Son SJ, Roh HW, Jung YS, Hong CH, Lee SY, Kim KP, -positive mild cognitive impairment and Alzheimer's disease. Mol Brain, 19(1):(2026) [pubmed] |
Keyword List
| submitter keyword: Alzheimer’s disease, Liquid chromatography-tandem mass spectrometry |
| Biomarker, Amyloid , Mild cognitive impairment, Proteomics, Platelets |
Contact List
| Kwang Pyo Kim |
|---|
| contact affiliation | Department of Applied Chemistry, Institute of Natural Science, Kyung Hee University, Yongin 17104, Republic of Korea |
| contact email | kimkp@khu.ac.kr |
| lab head | |
| Andrew Kim |
|---|
| contact affiliation | Seoul National University |
| contact email | kkim39@snu.ac.kr |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
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| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD067460
- Label: PRIDE project
- Name: In-Depth Platelet Proteomic Analysis in Various Dementia Stages: Unveiling Biomarkers for Alzheimer's Disease
