PXD067440

PXD067440 is an original dataset announced via ProteomeXchange.

Title	Metabolic Reprogramming of Cholesterol and Energy Pathways Underlies the Renoprotective Effect of Jianpi Yishen Formula in Chronic Kidney Disease
Description	This proteomics analysis in this study examined renal tissue protein expression profiles in adenine-induced chronic kidney disease (CKD) rats, focusing on the differences between the CKD group and the group treated with a high dose of Jianpi Yishen (JPYS) formula. It revealed that JPYS induces significant proteome reprogramming, with differentially expressed proteins distributed across subcellular compartments such as the cytoplasm, extracellular space, and mitochondria, and enriched in pathways including energy production and conversion. This provides insights into the proteomic basis underlying JPYS's renoprotective effects in CKD.
HostingRepository	iProX
AnnounceDate	2025-08-16
AnnouncementXML	Submission_2025-08-18_00:32:20.482.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Guandong Li
SpeciesList	scientific name: Rattus norvegicus; NCBI TaxID: 10116;
ModificationList	No PTMs are included in the dataset
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2025-08-18 00:31:54	ID requested
⏵ 1	2025-08-18 00:32:20	announced

Dataset with its publication pending

submitter keyword: Chronic kidney disease, Jianpi Yishen formula, Cholesterol Metabolic Reprogramming

Yuyan Li
contact affiliation	The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine
contact email	15919858357@163.com
lab head
Guandong Li
contact affiliation	The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine
contact email	1165775891@qq.com
dataset submitter

iProX dataset URI