⮝ Full datasets listing
PXD067380
PXD067380 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Drug tolerant KRAS mutant cancer cells |
| Description | KRAS inhibitors such as Sotorasib and Adagrasib are reshaping the treatment landscape for G12C mutant cancers, yet durable responses remain limited by the emergence of drug tolerant persister (DTP) cells that survive initial therapy and drive relapse. Here, we identify a metabolic program centered on α ketoglutarate (α KG) that enables KRAS G12C–mutant pancreatic and lung cancer cells to withstand inhibitor pressure. |
| HostingRepository | jPOST |
| AnnounceDate | 2026-04-22 |
| AnnouncementXML | Submission_2026-04-21_16:59:57.002.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Non peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Shigeki Aoki |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
| ModificationList | S-carboxamidomethyl-L-cysteine; L-methionine sulfoxide |
| Instrument | Q Exactive |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2025-08-15 00:44:43 | ID requested | |
| ⏵ 1 | 2026-04-21 16:59:57 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: KRAS, NSCLC, PDAC, Sotorasib, Adagrasib |
Contact List
| Shigeki Aoki | |
|---|---|
| lab head | |
| Shigeki Aoki | |
| contact affiliation | Chiba University |
| dataset submitter | |
Full Dataset Link List
| jPOST dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.jpostdb.org/JPST003998/ |
