PXD067346

PXD067346 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Persistent immune, coagulation and cardiac dysregulation predict late post discharge mortality in children with severe malnutrition.
Description	Children with complicated severe malnutrition (CSM) face high mortality after hospital discharge, yet the underlying mechanisms remain poorly understood. While early post-discharge mortality (<2 months) has been linked to a sepsis-like inflammatory profile at discharge, it is unclear whether this persists and contributes to late post-discharge mortality (LPDM; 2 to 6 months post-discharge). This study investigated whether immune, inflammatory, and endothelial dysfunction at 2 months post-discharge are associated with LPDM in children recovering from CSM. We conducted a case-control study nested within a randomized placebo-controlled trial of daily co-trimoxazole in HIV-negative children aged 2 to 59 months with CSM in four Kenyan hospitals. Cases were children who died between 2 and 6 months post-discharge; controls were survivors frequency-matched by sex, site, and trial arm. We used untargeted Tandem Mass Tagging based proteomics to quantify components of the plasma protein expression profiles associated with LPDM of children with CSM.
HostingRepository	MassIVE
AnnounceDate	2025-09-03
AnnouncementXML	Submission_2025-09-03_01:44:00.754.xml
DigitalObjectIdentifier
ReviewLevel	Non peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Elisha Omer
SpeciesList	scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2025-08-14 03:44:30	ID requested
⏵ 1	2025-09-03 01:44:01	announced

Publication List

no publication

no publication

Keyword List

submitter keyword: Complicated severe malnutrition, post-discharge mortality, inflammation, immunosuppression, coagulation, endothelial activation, cardiac dysfunction, DatasetType:Proteomics

submitter keyword: Complicated severe malnutrition, post-discharge mortality, inflammation, immunosuppression, coagulation, endothelial activation, cardiac dysfunction, DatasetType:Proteomics

Contact List

Dr. James M. Njunge
contact affiliation	KEMRI Wellcome Trust
contact email	JNjunge@kemri-wellcome.org
lab head
Elisha Omer
contact affiliation	KEMRI-Wellcome Trust
contact email	eomer@kemri-wellcome.org
dataset submitter

Full Dataset Link List

MassIVE dataset URI
Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive-ftp.ucsd.edu/v10/MSV000098824/

MassIVE dataset URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive-ftp.ucsd.edu/v10/MSV000098824/