PXD067156

PXD067156 is an original dataset announced via ProteomeXchange.

Title	Bipolar and schizophrenia risk gene AKAP11 encodes an autophagy receptor coupling the regulation of PKA kinase network homeostasis to synaptic transmission
Description	AKAP11 deficiency is associated with autophagy-regulated PKA and neuronal activity in mouse brains. We hypothesized that the differentially expressed proteins (DEPs) and phospho-proteins (pDEPs) in AKAP11 conditional KO mice and human iPSC-induced neurons (iNs) could be identified as potential AKAP11-PKA targets. We have generated AKAP11 F/F; Syn-Cre KO mice, AKAP11-eGFP;Syn-cre KI mice, AKAP11 KO iNs from human iPSCs using CRISPR/Cas9 and constitutive AKAP11 knockout mice
HostingRepository	PRIDE
AnnounceDate	2025-12-08
AnnouncementXML	Submission_2025-12-07_19:23:37.189.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Zhiping Wu
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090;
ModificationList	phosphorylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2025-08-09 17:31:56	ID requested
⏵ 1	2025-12-07 19:23:38	announced

10.1038/s41467-025-66356-w;

Lee YK, Xiao C, Zhou X, Wang L, McReynolds M, Wu Z, Han X, Purisic E, Kim H, Li X, Pang Z, Dai J, Peng J, Yang N, Yue Z, Bipolar and schizophrenia risk gene AKAP11 encodes an autophagy receptor coupling the regulation of PKA kinase network homeostasis to synaptic transmission. Nat Commun, 16(1):10792(2025) [pubmed]

submitter keyword: mouse models, synaptic transmission, ER-resident autophagy-related proteins VAPA/B, bipolar disorder (BD), protein kinase A (PKA), PKA-RI., electrophysiology,AKAP11, multi-omics, cell biology, schizophrenia (SCZ), human induced neurons, GSK3a/b, SPHKAP

Junmin Peng
contact affiliation	St. Jude Children's Research Hospital
contact email	junmin.peng@stjude.org
lab head
Zhiping Wu
contact affiliation	St. Jude Children's Research Hospital
contact email	zhiping.wu@stjude.org
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/12/PXD067156

PRIDE project URI

• PRIDE
  1. PXD067156
     1. Label: PRIDE project
     2. Name: Bipolar and schizophrenia risk gene AKAP11 encodes an autophagy receptor coupling the regulation of PKA kinase network homeostasis to synaptic transmission