PXD067149

PXD067149 is an original dataset announced via ProteomeXchange.

Title	Proteomic Profiling Unraveling the Role of Lactate Dehydrogenase A in Vascular Repair and Functional Recovery After Spinal Cord Injury
Description	This study employed label-free quantitative proteomics to profile the spinal cord tissue at multiple time points post-injury, aiming to uncover altered molecular pathways associated with endothelial cell dysfunction and repair. The proteomic analysis revealed lactate dehydrogenase A (LDHA) as a significantly upregulated protein at day post-injury 7 (DPI-7) and a potential regulator of vascular endothelial growth factor (VEGF)-VEGF receptor 2 (VEGFR2) signaling. Pharmacological inhibition of LDHA using FX-11 exacerbated oxidative stress in endothelial cells, suppressed their proliferation, hindered angiogenesis, and aggravated neurodegeneration and microglial accumulation at the lesion epicenter. These findings suggest that LDHA acts as a metabolic regulator of endothelial cell survival and angiogenic signaling under injury conditions.
HostingRepository	PRIDE
AnnounceDate	2026-01-16
AnnouncementXML	Submission_2026-01-15_23:13:33.998.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Manjeet Chopra
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2025-08-09 08:36:07	ID requested
⏵ 1	2026-01-15 23:13:34	announced

10.1021/ACSCHEMNEURO.5C00701;

submitter keyword: None

Hemant Kumar
contact affiliation	Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Ahmedabad
contact email	hemant@niperahm.res.in
lab head
Manjeet Chopra
contact affiliation	National Institute of Pharmaceutical Education and Research, Ahmedabad
contact email	chopramanjeet777@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/01/PXD067149

PRIDE project URI

• PRIDE
  1. PXD067149
     1. Label: PRIDE project
     2. Name: Proteomic Profiling Unraveling the Role of Lactate Dehydrogenase A in Vascular Repair and Functional Recovery After Spinal Cord Injury